Published work

Team members in bold
* equal contribution
^ corresponding author

Guièze R, Liu VM, Rosebrock D, Jourdain AA, Hernández-Sánchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygün O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND, Wierda WG, Livak KJ, Letai AG, Neuberg D, Harper JW, Carr SA, Piccioni F, Ott CJ, Leshchiner I, Johannessen CM, Doench J, Mootha VK, Getz G, Wu CJ^.
Mitochondrial reprogramming underlies resistance to BCL-2 inhibition in lymphoid malignancies.
Cancer Cell, 2019

Viny AD, Bowman RL, Liu Y, Lavallée VP, Eisman SE, Xiao W, Durham BH, Navitski A, Park J, Braunstein S, Alija B, Karzai A, Csete IS, Witkin M, Azizi E, Baslan T, Ott CJ, Pe'er D, Dekker J, Koche R, Levine RL^.
Cohesin members Stag1 and Stag2 display distinct roles in chromatin accessibility and topological control of HSC self-renewal and differentiation.
Cell Stem Cell, 2019

Sharifnia T^, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, Zhang T, Gray NS, Clarke PA, Blagg J, Workman P, Sommer J, Hornicek F, Root DE, Hahn WC, Bradner JE, Wong KK, Clemons PA, Lin CY^, Kotz JD^, Schreiber SL^.
Small-molecule targeting of brachyury transcription factor addiction in chordoma.
Nature Medicine, 2019

Fulciniti M*, Lin CY*, Samur MK, Lopez MA, Singh I, Lawlor MA, Szalat RE, Ott CJ, Avet-Loiseau H, Anderson KC, Young RA, Bradner JE, Munshi NC^.
Non-overlapping control of transcriptome by promoter- and super-enhancer-associated dependencies in multiple myeloma.
Cell Reports, 2018

Ott CJ*^, Federation AJ*, Schwartz LS, Kasar S, Klitgaard JL, Lenci R, Li Q, Lawlor M, Fernandes SM, Souza A, Polaski D, Gadi D, Freedman ML, Brown JR^, Bradner JE^.
Enhancer architecture and essential core regulatory circuitry of chronic lymphocytic leukemia.
Cancer Cell, 2018

Peeken JC, Jutzi JS, Wehrle J, Koellerer C, Staehle HF, Becker H, Schoenwandt E, Seeger TS, Schanne DH, Gothwal M, Ott CJ, Gründer A, Pahl HL^.
Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms.
Blood, 2018

Gechijian LN*, Buckely DL*, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS^, Bradner JE^.
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
Nature Chemical Biology, 2018

Shortt J*, Ott CJ*, Johnstone R^, Bradner JE^.
A chemical probe toolbox for dissecting the cancer epigenome.
Nature Reviews Cancer, 2017

Ott CJ, Wu CJ^.
HDAC inhibitors finally open up: chromatin accessibility signatures of CTCL.
Cancer Cell, 2017

Winter GE*, Mayer A*, Buckley DL*, Erb MA*, Roderick JE, Vittori S, Reyes JM, di Iulio J, Souza A, Ott CJ, Roberts JM, Zeid R, Scott TG, Paulk J, Lachance K, Olson CM, Dastjerdi S, Bauer S, Lin CY, Gray NS, Kelliher MA, Churchman LS^, Bradner JE^.
BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment.
Molecular Cell, 2017

Ott CJ^.
Opportunities for targeting gene regulatory factors in B-cell acute lymphoblastic leukemia.
International Journal of Hematologic Oncology, 2017

Hogg SJ*, Vervoot SJ*, Deswal S, Ott CJ, Li J, Cluse LA, Beavis PA, Darcy PK, Martin BP, Spencer A, Traunbauer AK, Sadovnik I, Bauer K, Valent P, Bradner JE, Zuber J, Shortt J^, Johnstone RW^.
BET-Bromodomain inhibitors engage the host immune system and regulate expression of the immune checkpoint ligand PD-L1.
Cell Reports, 2017

Koblan LW*, Buckley DL*, Ott CJ*, Fitzgerald ME*, Ember S, Zhu J-Y, Lui S, Roberts JM, Remillard D, Vittori S, Zhang W, Schonbrunn E, Bradner JE^.
Assessment of bromodomain target engagement by a series of BI2536 analogues with miniaturized BET-BRET.
ChemMedChem, 2016

Yang S, Ott CJ, Rossmann MP, Superdock M, Zon LI, Zhou Y^.
Chromatin immunoprecipitation and an open chromatin assay in zebrafish erythrocytes.
Methods Cell Biology, 2016

Koo SJ^, Fernández-Montalván AE, Badock V, Ott CJ, Holton SJ, von Ahsen O, Toedling J, Vittori S, Bradner JE, Gorjánácz M^.
ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication.
Oncotarget, 2016

Shu S*, Lin CY*, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Huh SJ, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, Peluffo G, Brown J, D'Santos C, Krop IE, Dillon D, McKeown M, Ott C, Qi J, Ni M, Rao PK, Duarte M, Wu SY, Chiang CM, Anders L, Young RA, Winer EP, Letai A, Barry WT, Carroll JS, Long HW, Brown M, Liu XS, Meyer CA, Bradner JE^, Polyak K^.
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.
Nature, 2016

Viny AD*, Ott CJ*, Spitzer B, Rivas M, Meydan C, Paplexi E, Yelin D, Shank K, Reyes J, Chiu A, Romin Y, Boyko V, Thota S, Maciejewski JP, Melnick A, Bradner JE^, Levine RL^.
Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.
Journal of Experimental Medicine, 2015

Knoechel B*, Roderick JE*, Williamson KE, Zhu J, Lohr JG, Cotton MG, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F, Silver SJ, Jain M, Pearson D, Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A, Stegmaier K, Kung AL, Root DE, Bradner JE, Aster JC, Kelliher MA^, Bernstein BE^.
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
Nature Genetics, 2014

Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, Wong KK, Bradner JE, Kaelin WG Jr^.
The myeloma drug lenalidomide promotes cereblon-dependent destruction of Ikaros proteins.
Science, 2014

Ott CJ^.
Promising new strategies to target gene regulatory factors in T-cell acute lymphoblastic leukemia. International Journal of Hematologic Oncology, 2014

Yigit E, Bischof JM, Zhang Z, Ott CJ, Kerschner JL, Leir S-H, Buitrago-Delgado E, Zhang Q, Wang JP, Widom J, Harris A^.
Nucleosome mapping across the CFTR locus identifies novel regulatory factors.
Nucleic Acids Research, 2013

Ott CJ*, Kopp N*, Bird L, Paranal RM, Qi J, Bowman T, Rodig SJ, Kung KL, Bradner JE^, Weinstock DM^.
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.
Blood, 2012

Bischof JM, Ott CJ, Leir S-H, Gosalia N, Cotton CU, Crawford GE, Harris A^.
A genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function.
Thorax, 2012

Ott CJ, Bischof JM, Unti KM, Gillen AE, Leir S-H, Harris A^.
Nucleosome occupancy reveals regulatory elements of the CFTR promoter.
Nucleic Acids Research, 2012

Zhang Z, Ott CJ, Lewandowska MA, Costa FF, Leir S-H, Bischof JM, Soares MB, Harris A^.
Molecular mechanisms controlling CFTR gene expression in the airway.
Journal of Cellular and Molecular Medicine, 2012

Ott CJ, Harris A^.
Genomic approaches for the discovery of CFTR regulatory elements.
Transcription, 2011

Ott CJ, Harris A^.
Genomic approaches to studying CFTR transcriptional regulation.
Methods in Molecular Medicine: Cystic Fibrosis Protocols and Diagnosis, 2011

Ott CJ, Blackledge NP, Kerschner JL, Leir S-H, Crawford GE, Cotton CU, Harris A^.
Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus.
Proceedings of the National Academy of Sciences, 2009

McCarthy VA, Ott CJ, Phylactides M, Harris A^.
Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression.
Biochimica et Biophysica Acta, 2009

Ott CJ, Suszko M, Blackledge NP, Wright JE, Crawford GE, Harris A^.
A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.
Journal of Cellular and Molecular Medicine, 2009

Ott CJ, Blackledge NP, Leir S-H, Harris A^.
Novel regulatory mechanisms for the CFTR gene.
Biochemical Society Transactions, 2009

Chen Y, Ott CJ, Townsend K, Subbaiah P, Aiyar A, Miller WM^.
Cholesterol supplementation during production increases the infectivity of retroviral and lentiviral vectors pseudotyped with the vesicular stomatitis virus glycoprotein (VSV-G).
Biochemical Engineering Journal, 2009

Blackledge NP, Ott CJ, Gillen A, Harris A^.
An insulator element 3' to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells. Nucleic Acids Research, 2009

Elkahwaji JE, Ott CJ, Janda LM, Hopkins WJ^.
Mouse model for acute bacterial prostatitis in genetically distinct inbred strains.
Urology, 2005

Sears J, Ujihara M, Wong S, Ott C, Middledorp J, Aiyar A^.
EBNA1 binds chromosomes using amino-terminal AT-hooks.
Journal of Virology, 2004

Hopkins WJ^, Elkahwaji JE, Heisey DM, Ott CJ.
Inheritance of susceptibility to induced Escherichia coli bladder and kidney infections in female C3H/HeJ mice.
Journal of Infectious Diseases, 2003